El Kazzouli Saïd

Ecole d’ingénieur BiomedTech

2004 : Ph.D. en Química Orgánica
Universidad de Orléans, Institute of Organic and Analytical Chemistry, Orléans, France. Supervisor: Profesor Gérald Guillaumet, Presidente de la Universidad de Orléans en
colaboración con el Professor Abderrahim Mouaddib, Universidad Cadi Ayyad. 
Título de la disertación: "Solid support synthesis of various heterocycles from a common
synthon. Development and pharmacological evaluation of imidazo[1,2-a]pyridine derivatives as melatonin analogues", Expertise: multi-step synthesis, imidazo[1,2- a]pyridines, melatonin analogues, palladium and copper–catalyzed reactions, solid
support synthesis, microwave synthesis.

2000 :  M.S. en Química Orgánica
Universidades de Orléans, París V y París XI
Título de la Tesis: "Support solid synthesis of large C-terminal peptide aldehyde:
application to chemoselective ligation". Expertise: solid phase synthesis, peptide chemistry.
Centre National de la Recherche Scientifique (CNRS), Centre de Biophysique
Moléulaire, Orléans, France. Supervisor: Agnès Delmas, Ph.D.

1997 :   B.S. en Química, Faculté des Sciences et Techniques (FST), Beni Mellal, Morocco.


Química Médica (oncología, imaginería médica y vectorización de productos activos). Química Orgánica (metodologías de síntesis, química verde y catálisis). Química Analítica (caracterización y valorización de sustancias naturales).

2013-Actualidad: Euro-Mediterranean University of Fes (UEMF), Morocco. Diseño y síntesis de moléculas bioactivas, entrega de drogas por macromoléculas,   química medioambiental, química verde, flotación por espuma de fosfatos y catálisis.

2009-2013: Institute of Nanomaterials  and  Nanotechnology,  Moroccan  Foundation  for Advanced Sciences, Innovations and Research (MAScIR), Rabat, Morocco. Diseño y síntesis de moléculas  bioactivas, entrega de drogas por dendrímeros, flotación por espuma de fosfatos y catalysis homogénea.

2006-2009:  National Institutes of Health (NIH), National Cancer Institute (NCI), Frederick, Maryland, Centre for Cancer Research, Laboratory of Medicinal Chemistry, USA. 
Investigador Postdoctoral (IRTA Fellow): Rational drug design and multi-step synthesis of antitumor agents, purification and characterization of biologically active diacylglycerol-lactones (DAG-lactones). Expertise: solid phase synthesis, parallel synthesis, combinatorial chemistry, diacylglycerol-lactones (DAG-lactones), protein kinase C (PKC), C1-domains.

2004-2006: Universidad de Orléans, Institute of Organic and Analytical Chemistry, Orléans,

2005-2006: Investigador postdoctoral en Heterocyclic Chemistry: Synthesis of herbicide, Expertise: indole chemistry, anionic reactions, in collaboration with Syngenta, Basel, Switzerland.

2005: Investigador posdoctoral en Nucleosides Chemistry: Synthesis of new antiviral drugs, Expertise: nucleosides chemistry, palladium–catalyzed reactions, solid support synthesis, microwave synthesis. France.

2004:  Supervisor: Professor Gérald Guillaumet, President of Orleans University, Investigador postdoctoral en Heterocyclic Chemistry: Synthesis of new pyrimido[4,5-b][1,4]oxazines, Expertise: pyrimido[4,5-b][1,4]oxazines, palladium-catalyzed N- arylation, microwave synthesis. France


  1. 1,4-Dioxins, oxathiins, dithiins and their benzo derivatives, Book chapter 8.2, Comprehensive heterocyclic Chemistry IV, Tikad, A.; El Kazzouli. S.; Guillaumet, G.2020, under press
  2. Direct arylation and Suzuki-Miyaura coupling of imidazo[1,2-a]pyridines catalyzed by (SIPr)Pd(allyl)Cl complex under microwave-irradiation. El Abbouchi, A.; Koubachi, J.; El Brahmi, N.; El Kazzouli. S. Med J. Chem.2019, 9, 347.(IF = 1.45).
  3. Unusual rearrangement of imidazo[1,5-a]imidazoles and imidazo[1,2-b]pyrazoles into imidazo[1,5-a]pyrimidines and pyrazolo[1,5-a]pyrimidines, Gambouz, K.; Loubidi, M.; Tber, Z.; Driowy, M.; Allouchi, H.; El Kazzouli, S. Akssira, M.; Guillaumet, G. RSC Advances, 2019, 9, 29051. (IF = 3.05).
  4. Oxidative alkenylation of fused bicyclic heterocycles. Koubachi, J.; El Brahmi, N.; Guillaumet, G.; El Kazzouli, S.Eur. J. Org. Chem. 2019, 2568. (IF = 3.03).
  5. Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 1). Mignani, S.; Rodrigues, J.; Roy, R.; Shi, X.; Cenã, V.; ElKazzouli, S.;Majoral. J-P. Drug Discov. Today, 2019, 24, 1176. (IF = 6.88).
  6. Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 2). Mignani, S.; Rodrigues, J.; Roy, R.; Shi, X.; Cenã, V.; ElKazzouli, S.;Majoral. J-P. Drug Discov. Today, 2019, 24, 1184. (IF = 6.88).
  7. Palladium-catalyzed C3 arylations of 1H and 2H pyrazolo[4,3-b]pyridines on water: One pot direct C3-arylations of 1H and 2H series. Faarasse, S.; ElKazzouli, S.; Suzenet, F.; Guillaumet, G., J. Org. Chem.2018, 83, 12847-12854 (IF = 4.85).
  8. Synthesis and characterization of new organophilic clay. Preparation of polystyrene/clay nanocomposite, Ben-Yahia, A.; El Kazzouli, S.; Essassi, E.M.; Bousmina, M.M. Scientific Study and Research: Chemistry and Chemical Engineering, Biotechnology, Food Industry, 2018, 19, 193.
  9. Palladium-catalyzed C3 arylations of 1H and 2H pyrazolo[4,3-b]pyridines on water: One pot direct C3-arylations of 1H and 2H series. Faarasse, S. ElKazzouli, S.; Suzenet, F.; Guillaumet, G., Org. Lett. 2018, submitted.
  10. On Water” Direct C-3 Arylation of 2H-Pyrazolo[3,4-b]pyridines, Faarasse, S. ElKazzouli, S.; Naas, M.; Jouha, J.; Suzenet, F.; Guillaumet, G., J. Org. Chem. 2017, 82, 12300. (IF = 4.85)
  11. Original Multivalent Gold(III) and Dual Gold(III)–Copper(II) Conjugated Phosphorus Dendrimers as Potent Antitumoral and Antimicrobial Agents, Mignani, S.; El Brahmi, N.; El Kazzouli, S.; Laurent, R.; Ladeira, S.; Caminade, A-M.; Pedziwiatr-Werbicka, E.; Szewczyk, E. M.; Bryszewska, M.; Bousmina, M.; Cresteil, T.; Majoral, J-P. Molecular Pharmaceutics. 2017, 14, 4087. (IF = 4.44)
  12. Anticancer copper(II) phosphorus dendrimers are potent proapoptotic Bax activators.Mignani,S.ElBrahmi,N.;Eloy, L.; Poupon, J.; Nicolas, V.; Steinmetz, A.; El Kazzouli,S.;Bousmina,M. ;Blanchard-Desce, M.; Caminade, A-M.; Majoral, J-P.; Cresteil, T.Eur. J.Med.Chem. 2017, 132, 142.(IF = 4.5)
  13. Symmetrical and unsymmetrical incorporation of active biological monomers on the surface of phosphorus dendrimers.ElBrahmi,N.;El Kazzouli,S.;Mignani,S.; Laurent. R.; Ladeira. S.;Caminade,A-M.;Bousmina,M.; Majoral,J-P. Tetrahedron. 2017, 73, 1331.(IF= 2.64)
  14. A  novel  class  of  ethacrynic  acid  derivatives  as  promising  drug-like  potent  generation  of anticancer agents with established mechanism of action.Mignani,S.ElBrahmi,N.El Kazzouli,S.:Eloy,L.;Courilleau,D.;Caron, J.S.Bousmina,M.Caminade,A-M.Cresteil, T. Majoral,J-P. Eur. J.Med.Chem. 2016, 122, 656.(IF = 4.5)
  15. Functionalization  of  Indazoles  by  Means  of  Transition  Metal-Catalyzed  Cross-Coupling Reactions. ElKazzouli, S.; Guillaumet, G.,Tetrahedron. 2016, 72, 6711. (IF= 2.64)
  16. Synthesis and  characterization  of  nanostructured  palladium  perovskites:  Evaluation  otheir catalyticactivity incross-coupling chemistry,Essoumhi,A.Solhy,A.ElKazzouli,S.J. Mater. Environ. Sci. 2016, 7, 1080.(IF= 1.2)
  17. Palladium-catalyzedoxidativedirectC3-andC7-alkenylationsofindazoles:Applicationtothe synthesisofGamendazole.Naas,M.El Kazzouli, S.; Essassi,EM.Bousmina,M.;Guillaumet, G. Org. Lett. 2015, 17, 4320. (IF=6.4)
  18. AdvancesindirectC-Harylationof5,5,6,5and6,6- fusedheterocyclescontainingheteroatoms (N,O,S).ElKazzouli,S.;Koubachi,J.;ElBrahmi,N.;Guillaumet,G.RSCAdvances,2015, 7, 3915.(IF=3.4)
  19. Investigationsindendrimerspacerevealsolidandliquidtumorgrowth-inhibitionbyoriginal phosphorus-baseddendrimersand corresponding monomersanddendronswith ethacrynicacid motifs.ElBrahmi,N.;Mignani,S.;Caron,J.;ElKazzouli,S.;Bousmina,M.;Caminade,A- M.;Cresteil,T.; Majoral,J-P. Nanoscale, 2015, 7, 3915.(IF=7.4)
  20. Palladium-catalyzeddirectC7-arylationofsubstitutedindazoles.Naas,M.;ElKazzouli,S.; Essassi, E.M.;Bousmina,M.;Guillaumet, G.J. Org.Chem. 2014. 79, 7286.(IF =4.85)
  21. Ceria-supportedcoppernanoparticles:AhighlyefficientandrecyclablecatalystforN-arylation ofindole.Amadine,O.;Maati,H.;Abdelouhadi, K.;Fihri,A.;ElKazzouli, S.;Len,C.;El Bouari, A.;Solhy. A.JournalofMolecular CatalysisA:Chemical,2014, 395, 409.(IF=3.7)
  22. Functionalizationof imidazo[1,2-a]pyridinesby meansofmetal-catalyzedcross-coupling reactions– Areview. Koubachi,J.;El Kazzouli, S.;Bousmina, M.;Guillaumet, G.Eur. J. Org. Chem. 2014, 24, 5119.(IF =3.03)
  23. Review on Palladium-containing perovskites: Synthesis, physico-chemical properties and applications  icatalysis.  EssoumhiA.; El  Kazzouli,  S.; Bousmina, M.  J. Nanosci. Nanotechnol. 2014,14, 2012.(IF=1.56)
  24. DendrimerSpaceExploration:Inhibitionofprotein-proteininteractionsforthenextgeneration ofpharmaceuticals.Mignani,S.;ElKazzouli,S.;Bousmina,M.;Majoral,J-P.Chem.Rev. 2014, 114,1327.(IF=54.3)
  25. Dendrimerspaceconceptforinnovativenanomedicine:afuturisticvisioninmedicinal chemistry. Mignani, S.; El KazzouliM.; Bousmina, M.;  Majoral, Progress in Polymer Science, 2013, 38,993.(IF =26.84)
  26. Original multivalent copper(II)-conjugated phosphorus-dendrimers and corresponding mononuclearcopper(II)complexeswith anti-tumoralactivities.ElBrahmi, N.ElKazzouli, S. Mignani,S. Essassi,E. Aubert,G.Laurent,R.Caminade,A-M.Bousmina,M.Cresteil,T. Majoral,J-P. Molecular Pharmaceutics, 2013, 10,1459. (IF=4.4)
  27. Expandclassicaldrugadministrationwaysbyemergingroutesusingdendrimerdrugdelivery systems:aconciseoverview.Mignani,S.;ElKazzouli,M.;Bousmina,M.;Majoral, J-P. Advanced Drug Delivery Reviews, 2013, 65, 1316.(IF =12)
  28. Copperindendrimer’ssynthesisandapplicationsofcopperdendrimersystemsincatalysis:a conciseoverview.ElBrahmiN.;ElKazzouli,M.;Mignani,S.;Bousmina,M.;Majoral, J-P. Tetrahedron, 2013, 69, 3103.(IF=2.64)
  29. Microwave-assistedSuzuki-Miyauracross-coupling of free(NH)3-bromoindazoles.Benyahia, A.;Naas,M.;ElBrahmi,N.;ElKazzouli,S.;Essassi,EM.Majoral, J-P.Guillaumet,G. CurrentOrg. Chem. 2013,17, 304.(IF=2.16)



  1. Activités antitumorales d’une nouvelle famille de dérivés de l’acide ethacrynique,

N° de dépôt: 44038, 29/11/2018. Submitted to PCT, Int. Appl. In 2019.

El Kazzouli S.; Abdelmajid, Z.; El Brahmi N.; El Abbouchi A.; Boujdi K.; Bousmina M.; Ait Mouse H.; Tilaoui M.

Conferencia Plenaria : Copper(II)-conjugated phosphorus dendrimers: Synthesis and antitumoral activities.1ère Rencontre Internationale de Chimie Moléculaire, Chemiométrie et Applications (1ère RICMCA), 29-30 Mai 2014 à la FST de Beni Mellal, Morocco.

Conferencia invitada : Présentation des applications biotechnologiques & nantechnologiques dans le domaine pharmaceutique et Drug Design, Journée de la Biotechnologie, 19 March 2015, CNRST, Rabat, Morocco.

Conferencia invitada : Functionalisation of indazoles by direct arylation and oxydative alkenylation, 30 June 2015, Centre international universitaire pour la recherche, Orleans, France.

Conferencia invitada : Synthesis of phosphorus dendrimers functionalized by copper or ethacrynic acid derivatives: Evaluation of their anticancer activities. 08 Jully 2015, Institut de Chimie Organique et Analytique, University of Orléans, France.

Conferencia invitada :  Direct  C-H  alrylation  and  alkenylation  of  indazoles.  11 March  2016,  5th Spanish-Moroccan Symposium on Organic Chemistry, Casablanca, Morocco.

Conferencia invitada : Fonctionnalisation de l’imidazo[1,2-a]pyridine et de l’indazole par des réactions d’arylation directe et d’alcénylation oxydative, 6ème Rencontre Internationale sur la Chimiométrie, la Qualité et la Chimie Moléculaire, 22 April 2016, Beni Mellal, Morocco.

Presentación oral : Synthesis of new drug-phosphorus dendrimer conjugates and their evaluation as anticancer agents 28 July 2016, Lyon, France.

Conferencia invitada: Synthesis and biological evaluation of a novel class of ethacrynic acid derivatives, Workshop International “Molécules Bioactives et Biomatériaux” 24/03/2017, FST Mohammedia, Univerity of Casablanca.

Conferencia invitada: Fonctionnalisation des indazoles et azaindazoles par des réactions d’activation de la liaison C-H, 10ème édition du Colloque Franco-Roumain de Chimie Appliquée (COFrRoCA) 26-28/06/2018, Universty of Bacau, Romania.

Video-Conferencia : C-H functionnalization of indazoles and azaindazole, 19th Global Chemistry conferences, 20-21 March 2019, New York, USA

Conferencia clave : Synthesis and biological applications of dendrimers, 2th International Conference on Material Science and Material Chemistry, 20-21 March 2019, London, UK

Conferencia invitada : Design and synthesis of drug-loaded dendrimers as anticancer agents, International conference in applied and theory of nanostructures, 18-18 June 2019, Kenitra, Morocco


Química Analítica;

Química Orgánica;

Química General;

Síntesis, caracterización y aplicaciones de polímeros macromoleculares.