EL BRAHMI Nabil
EL BRAHMI Nabil
Ecole d’ingénieur BiomedTech
n.elbrahmi@ueuromed.org
2013 : Doctorat National Marocain : Faculté des Sciences, Université Mohammed V, Agdal, Rabat- Laboratoire de Chimie de Coordination CNRS, Toulouse, France).
2007 : Diplôme d’Etudes Supérieures Approfondies DESA. (BAC+6) : Faculté des Sciences, Université Mohammed V, Agdal, Rabat ; UFR : Pharmacochimie.
Chimie Organique/Chimie Médicinale.
2019 : Professeur Habilité. Université Euromed de Fès.
2014 : Professeur Assistant. Université Euromed de Fès.
2013 : Post-doctoral. Université Euromed de Fès & Laboratoire de Chimie de Coordination, Toulouse, France.
2011: Ingénieur chercheur. Laboratoire de Chimie de Coordination (CNRS, Toulouse, France)
P1) Near-infrared emitting poly(amidoamine) dendrimers with an anthraquinone core towards versatile noninvasive biological imaging. K. Jouad, S. V. Eliseeva, G. Collet, C. Colas, D. Da Silva, M-A. Hiebel, N. El Brahmi, M. Akssira, S. Petoud, S. El Kazzouli, F. Suzenet, Biomacromolecules, 2022, accepted (IF = 6.9). P2) Synthesis and evaluation of a novel class of ethacrynic acid derivatives containing triazoles as potent anticancer agents. A. El Abbouchi, N. El Brahmi, M-A. Hiebel, J. Bignon, G. Guillaumet, F. Suzenet, S. El Kazzouli. Bioorg. Chem. 2021, 115, 105293 (IF = 5.27). P3) Regioselective C-H Functionalization of the Six-Membered Ring of the 6,5-Fused Heterocyclic Systems: An Overview S. Faarasse, N. El Brahmi, G. Guillaumet, S. El Kazzouli. Molecules. 2021, 26, 5763 (IF = 4.41). P4) A Regioselective C7 Bromination and C7 Palladium-catalyzed Suzuki–Miyaura Cross-coupling Arylation of 4-Substituted NH-free Indazoles K. Boujdi, N. El Brahmi, J. Graton, D. Dubreuil, S. Collet,b M. Mathé-Allainmat, M. Akssira, J. Lebreton, S. El Kazzouli. RCS Advences. 2021, 11, 7107-7114 (IF = 3.12). P5) Design, Synthesis and Biological Evaluation of Ethacrynic Acid Derivatives Bearing Sulfonamides as Potent Anti-Cancer Agents. A. El Abbouchi, N. El Brahmi, M-A. Hiebel, J. Bignon, G. Guillaumet, F. Suzenet, S. El Kazzouli. Bioorg. Med. Chem. Lett. 2020, 30, 127426 (IF = 2.7). P6) Direct arylation and Suzuki-Miyaura coupling of imidazo[1,2-a]pyridines catalyzed by (SIPr)Pd(allyl)Cl complex under microwave-irradiation A. El Abbouchi, J. Koubachi, N. El Brahmi, S. El Kazzouli. Mediterrr. J. Chem. 2019, 9, 347-354 (IF = 0.85). P7) Dendrimer for Templating the Growth of Porous Catechol- Coordinated Titanium Dioxide Frameworks: Toward Hemocompatible Nanomaterials N. Katir, N. Marcotte, S. Michlewska, M. Ionov, N. El Brahmi, M. Bousmina, J. P. Majoral, M. Bryszewska, A. El Kadib. ACS Applied Nano Materials. 2019, 2, 2979-2990 (5.097). P 8) Oxidative Alkenylation of Fused Bicyclic Heterocycles J. Koubachi, N. El Brahmi, G. Guillaumet, S. El Kazzouli. Eur. J. Org. Chem. 2019, 15, 2568-2586 (IF = 3.03). P9) Interfacial complexation driven three-dimensional assembly of cationic phosphorus dendrimers and graphene oxide sheets N. Katir, A. Benayad, D. Rouchon, N. Marcotte, N. El Brahmi, J. P. Majoral, B. Bousmina, A. El Kadib. Nanoscale Adv. 2019, 1, 314-321 (4.55). P10) Elucidating the role of surface chemistry on cationic phosphorus dendrimer- siRNA complexation M. A. Deriu, N. Tsapis, M. Noiray, G. Grasso, N. El Brahmi, S. Mignani, J. P. Majoral, E. Fattal, A. Danani. Nanoscale. 2018, 10, 10952-10962 (IF = 6.97). S. Mignani, N. El Brahmi, T. Cresteil, J. P. Majoral. Oncology, 2018, 94(5), 324-328 (IF = 2.6). S. Mignani, N. El Brahmi, S. El Kazzouli, R. Laurent, S. Ladeira, A. M. Caminade, E. Pedziwiatr-Werbicka, E. Szewczyk, M. Bryszewska, M. Bousmina, T. Cresteil, J. P. Majoral. Mol. Pharm. 2017, 14, 11, 4087-4097 (IF = 4.39). I. Posadas, L. Romero-Castillo, N. El Brahmi, D. Manzanares, S. Mignani, J. P. Majoral, V. Cena, PNAS USA. 2017, 114, E7660-E7669 (IF = 11.2). A. Bohr, N. Tsapis, I. Andreana, A. Chamarat, C. Foged, C. Delomenie, M. Noiray, N. El Brahmi, J. P. Majoral, S. Mignani, E. Fattal, Biomacromolecules, 2017, 18(8), 2379-2388 (IF = 5.67). P15) Anticancer copper(II) phosphorus dendrimers are potent proapoptotic Bax activators. S. Mignani, N. El Brahmi, L. Eloy, J. Poupon, V. Nicolas, A. Steinmetz, S. El Kazzouli, M. Bousmina, M. Blanchard-Desce, A. M. Caminade, J. P. Majoral, T. Cresteil. Eur. J. Med. Chem. 2017, 132, 142-156 (IF = 4.83). P16) Symmetrical and unsymmetrical incorporation of active biological monomers on the surface of phosphorus dendrimers. N. El Brahmi, S. El Kazzouli, S. Mignani, R. Laurent, S. Ladeira, A. M. Caminade, M. Bousmina, J. P. Majoral. Tetrahedron. 2017, 73, 1331-1341 (IF = 2.38). P17) Orthogonal Synthesis of Covalent Polydendrimer Frameworks by Fusing Classical and Onion-Peel Phosphorus-Based Dendritic Units. N. Katir, N. El Brahmi, N. Marcotte, J. P. Majoral, M. Bousmina, A. El Kadib. Macromolecules. 2016, 49, 5796-5805 (IF = 5.99). P18) A Novel Class of Ethacrynic Acid Derivatives as Promising Druggable Potent Generation of Anticancer Agents with Established Mechanism of Action. S. Mignani, N. El Brahmi, S. El Kazzouli, L. Eloy, D. Courillaud, J. Caron, M. M. Bousmina, A. M. Caminade, T. Cresteil, J. P. Majoral. Eur. J. Med. Chem. 2016, 122, 656-673 (IF = 4.83). P19) Synthesis, Characterization and Biological Properties of New Hybrid Carbosilane- Viologen- Phosphorus Dendrimers. S. Moreno, A. Szwed, N. El Brahmi, K. Milowska, J. Kuroswka, E. Fuentes-Paniagua, E. Pedziwiatr-Werbicka, T. Gabryelak, N. Katir,; J. de la Mata, M. A. Munoz-Fernandez, R. Gomez Ramirez, A. M. Caminade, J. P. Majoral, M. Bryszewska. RCS Advences. 2015, 5, 25942-25958 (IF = 3.05). P20) Synthesis of Onion-Peel Nanodendritic Structures with Sequential Functional Phosphorus Diversity. N. Katir, N. El Brahmi, A. EL Kadib, S. Mignani, A. M. Caminade, M. Bousmina, J. P. Majoral. Chem. Eur. J. 2015, 21, 1-10 (IF = 5.16). P21) Advances in direct C- H arylation of 5, 5- 6, 5- and 6, 6- fused- heterocycles containing heteroatoms (N, O, S). S. El Kazzouli, J. Koubachi, N. El Brahmi, G. Guillaumet. RCS Advences. 2015, 5, 15292-15327 (IF = 3.05). P22) Investigations on dendrimer space reveal solid and liquid tumor growth- inhibition by original phosphorus- based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs. N. El Brahmi, S. Mignani, J. Caron, S. El Kazzouli, M. Bousmina, A. M. Caminade, T. Cresteil, J. P. Majoral. Nanoscale. 2015, 7, 3915-3922 (IF = 6.97). |
C1) Nabil El Brahmi, “New Copper (II) and Gold (III)-Loaded Phosphorus Dendrimers: Synthesis and Biological Evaluation” Mohammedia, Maroc 19 et 20 Septembre, 2018. C2) Nabil El Brahmi, “Metallodendrimers : Synthesis and biological applications”. Workshop international-Chimie Bio-Organique et Médicinale-. Fès, Maroc 22 Mars, 2017. C3) New Drug-Loaded Phosphorus Dendrimers: Their synthesis and anticancer activities Nabil. El Brahmi, S. El Kazzouli, S. Mignani, T. Cresteil, M. M. Bousmina, J. P. Majoral C4) Synthesis and characterization of new phosphorus-viologen-carbosilane dendrimers. S. Moreno, Nabil El Brahmi, E. Fuentes-Paniagua, F.J de la Mata, J. P Majoral, R. Gómez. 8th International Dendrimer Symposium, Madrid, Spain 23-27 June, 2013. C5) Synthèse, caractérisation et évaluation biologique de nouveaux complexes dendrimères-cuivre. Nabil El Brahmi, S. El Kazzouli, R. Laurent, S. Mignani, T. Cresteil, M. Essassi, A-M. Caminade, J-P. Costes, M. Bousmina, J-P. Majoral. 3ème Colloque Scientifique Franco-Marocain du LIA. Rabat, Maroc 15-17 Octobre, 2012. C6) Synthesis, Characterization and Biological Evaluation of New Drug-Loaded Phosphorus Dendrimers. Nabil El Brahmi, S. El Kazzouli, S. Mignani, T. Cresteil, M. Essassi, A-M. Caminade, J-P. Costes, M. Bousmina, J-P. Majoral. 3rd International Symposium on Biological Applications of Dendrimers. Toledo, Spain 5th-8th September, 2012. |
C1) Nabil El Brahmi, “New Copper (II) and Gold (III)-Loaded Phosphorus Dendrimers: Synthesis and Biological Evaluation” Mohammedia, Maroc 19 et 20 Septembre, 2018.
C2) Nabil El Brahmi, “Metallodendrimers : Synthesis and biological applications”. Workshop international-Chimie Bio-Organique et Médicinale-. Fès, Maroc 22 Mars, 2017.
C3) New Drug-Loaded Phosphorus Dendrimers: Their synthesis and anticancer activities
Nabil. El Brahmi, S. El Kazzouli, S. Mignani, T. Cresteil, M. M. Bousmina, J. P. Majoral
32nd International Conference of the Polymer Processing Society, Lyon, France 25-29 July, 2016.
C4) Synthesis and characterization of new phosphorus-viologen-carbosilane dendrimers.
S. Moreno, Nabil El Brahmi, E. Fuentes-Paniagua, F.J de la Mata, J. P Majoral, R. Gómez.
8th International Dendrimer Symposium, Madrid, Spain 23-27 June, 2013.
C5) Synthèse, caractérisation et évaluation biologique de nouveaux complexes dendrimères-cuivre.
Nabil El Brahmi, S. El Kazzouli, R. Laurent, S. Mignani, T. Cresteil, M. Essassi, A-M. Caminade, J-P. Costes, M. Bousmina, J-P. Majoral.
3ème Colloque Scientifique Franco-Marocain du LIA. Rabat, Maroc 15-17 Octobre, 2012.
C6) Synthesis, Characterization and Biological Evaluation of New Drug-Loaded Phosphorus Dendrimers.
Nabil El Brahmi, S. El Kazzouli, S. Mignani, T. Cresteil, M. Essassi, A-M. Caminade, J-P. Costes, M. Bousmina, J-P. Majoral.
3rd International Symposium on Biological Applications of Dendrimers. Toledo, Spain 5th-8th September, 2012.
C1) Nabil El Brahmi, “New Copper (II) and Gold (III)-Loaded Phosphorus Dendrimers: Synthesis and Biological Evaluation” Mohammedia, Maroc 19 et 20 Septembre, 2018.
C2) Nabil El Brahmi, “Metallodendrimers : Synthesis and biological applications”. Workshop international-Chimie Bio-Organique et Médicinale-. Fès, Maroc 22 Mars, 2017.
C3) New Drug-Loaded Phosphorus Dendrimers: Their synthesis and anticancer activities
Nabil. El Brahmi, S. El Kazzouli, S. Mignani, T. Cresteil, M. M. Bousmina, J. P. Majoral
32nd International Conference of the Polymer Processing Society, Lyon, France 25-29 July, 2016.
C4) Synthesis and characterization of new phosphorus-viologen-carbosilane dendrimers.
S. Moreno, Nabil El Brahmi, E. Fuentes-Paniagua, F.J de la Mata, J. P Majoral, R. Gómez.
8th International Dendrimer Symposium, Madrid, Spain 23-27 June, 2013.
C5) Synthèse, caractérisation et évaluation biologique de nouveaux complexes dendrimères-cuivre.
Nabil El Brahmi, S. El Kazzouli, R. Laurent, S. Mignani, T. Cresteil, M. Essassi, A-M. Caminade, J-P. Costes, M. Bousmina, J-P. Majoral.
3ème Colloque Scientifique Franco-Marocain du LIA. Rabat, Maroc 15-17 Octobre, 2012.
C6) Synthesis, Characterization and Biological Evaluation of New Drug-Loaded Phosphorus Dendrimers.
Nabil El Brahmi, S. El Kazzouli, S. Mignani, T. Cresteil, M. Essassi, A-M. Caminade, J-P. Costes, M. Bousmina, J-P. Majoral.
3rd International Symposium on Biological Applications of Dendrimers. Toledo, Spain 5th-8th September, 2012.
- Chimie Générale/Chimie Minérale (Cycle préparatoire 1ère année -EIBB)
- Chimie Organique I (Cycle préparatoire 1ère année -EIBB)
Brevets
- B1) Copolydendrimerscontainingheteroatoms M. Bousmina, N. Katir, A. El Kadib, N. El Brahmi, J.-P. Majoral, N. Marcotte. N° : WO 2017/222358 A2
- B2) Antitumor study of a novel class of ethacrynic acid derivatives S. El Kazzouli, A. Zyad, N. El Brahmi, A. El Abouchi, K. Boujdi, M. Bousmina, H. A. Mouse, M. Tilaoui. N° de dépôt : 44038